Research Journal of Biological Sciences
ISSN: Online 1993-6087ISSN: Print 1815-8846
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The Evaluation of the Immune Response and the Effects of the Mixture of (Nt + Ct) Proteins of the Circumsporozoite (CSP) of Plasmodium berghei and Plasmodium falciparum
Marianne Patricia Ntsama epse Foh Mengo , Giampietro Corradin and Silayuv Bongfen
Page: 1446-1451 | Received 21 Sep 2022, Published online: 21 Sep 2022
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Abstract
Malaria infection is initiated when an infected Anopheline mosquito injects sporozoites during a blood meal. The Circumsporozoite (CSP) protein is the major surface protein of plasmodium sporozoites and forms a dense coat on the parasite’s surface. Although, the C-terminal (Ct) portion or side of the CSP protein has been extensively studied as a malaria candidate vaccine, little is known about the N-terminal (Nt) portion and the mixture of the 2 portions (Nt + Ct) of this protein on the immune response. Our data suggest that the mixture (Nt + Ct) peptides responded well and much more better inhibition of invasion of hepatocytes was given by the use of that mixture than when Ct or Nt was used separately. The 2 peptides seem to play an important inhibitory role against the invasion of hepatocytes by sporozoites.
How to cite this article:
Marianne Patricia Ntsama epse Foh Mengo , Giampietro Corradin and Silayuv Bongfen . The Evaluation of the Immune Response and the Effects of the Mixture of (Nt + Ct) Proteins of the Circumsporozoite (CSP) of Plasmodium berghei and Plasmodium falciparum.
DOI: https://doi.org/10.36478/rjbsci.2008.1446.1451
URL: https://www.makhillpublications.co/view-article/1815-8846/rjbsci.2008.1446.1451