@article{MAKHILLRJBS200831210791,
    title = {The Evaluation of the Immune Response and the Effects of the Mixture of (Nt + Ct) Proteins of the Circumsporozoite (CSP) of <I>Plasmodium berghei</I> and <I>Plasmodium falciparum</I>},
    journal = {Research Journal of Biological Sciences},
    volume = {3},
    number = {12},
    pages = {1446-1451},
    year = {2008},
    issn = {1815-8846},
    doi = {rjbsci.2008.1446.1451},
    url = {https://makhillpublications.co/view-article.php?issn=1815-8846&doi=rjbsci.2008.1446.1451},
    author = {Marianne Patricia Ntsama epse Foh Mengo,Giampietro Corradin and},
    keywords = {Evaluation,immune response,circumsporozoite (CSP),plasmodium berghei,plasmodium falciparum},
    abstract = {Malaria infection is initiated when an infected Anopheline mosquito injects sporozoites during a blood meal. The Circumsporozoite (CSP) protein is the major surface protein of plasmodium sporozoites and forms a dense coat on the parasite’s surface. Although, the C-terminal (Ct) portion or side of the CSP protein has been extensively studied as a malaria candidate vaccine, little is known about the N-terminal (Nt) portion and the mixture of the 2 portions (Nt + Ct) of this protein on the immune response. Our data suggest that the mixture (Nt + Ct) peptides responded well and much more better inhibition of invasion of hepatocytes was given by the use of that mixture than when Ct or Nt was used separately. The 2 peptides seem to play an important inhibitory role against the invasion of hepatocytes by sporozoites.}
    }