Research Journal of Pharmacology
ISSN: Online 1993-6019ISSN: Print 1815-9362
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Abstract
A total of 12 healthy desert sheep were injected intramuscularly with multiple doses of 5 g kg-1 tylosin. Samples were collected at time 1, 3, 7 and 10 days after drug administrations. Tylosin was detected using microbiological method. Tylosin concentrations in different tissue were detected. High concentration of 61.78±5.83, 315.97±73.07 and 3956±645.59 µg g-1 were detected in liver, kidney and muscle, respectively at day 1. The highest concentrations of 19185±2966.9 µg g-1 were noted at the site of injection at day 1 and persisted for 10 days. Low concentrations of 1.00, 1.5±0.24 and 5.22±0.20 µg g-1 were noted in the liver, kidney and muscle at day 10, respectively. It is suggested that high tissue levels may create a reservoir of drug from which drug was released slowly into the circulation.
How to cite this article:
Samia A.A. Hassan , Sania A.I. Shaddad , I.B. ElTayeb , M.A. Omer , M.H. Al-Nazawi and A.M. Homeida . Detection of Tylosin Residue Levels Following Intramuscular Injection in Desert Sheep.
DOI: https://doi.org/10.36478/rjpharm.2008.1.3
URL: https://www.makhillpublications.co/view-article/1815-9362/rjpharm.2008.1.3