Research Journal of Pharmacology
ISSN: Online 1993-6019ISSN: Print 1815-9362
Abstract
Wounds and their management are fundamental in the practice of surgery. This Prospective cohort study was done to compare the efficacy of super oxidized solution versus Povidone Iodine in the management of lower limb diabetic ulcers. 100 patients were randomized into 2 groups for SOS and PI with 50 patients in each group. Wound assessments done at regular intervals on day 1, 9, 15 and 21 days and various wound outcome variables were compared. In a study of 100 patients, most patients were in the age group of 51‐60 years and 68% were male. There was rapid decrease in wound size in SOS group compared to PI group at day 21 and earlier appearance of granulation tissue in SOS group. Resolution of peri wound erythema and peri wound edema was earlier in SOS group compared to PI Group. There was shorter duration of hospital stay, earlier wound disinfection and more number of patients who underwent skin grafting before 21 days in SOS group. The results were statistically significant and in favour of SOS. Thus Super oxidized solution, has faster response in wound healing and gives better efficacy as compared to the traditional Povidone Iodine solution for use in wound care in management of lower limb Diabetic ulcers. On correlation of the wound outcome variables, we also noticed that the duration for formation of granulation day (r value=0.303, p value=0.002), peri wound erythema resolution day (r value=0.417, p value=0.000), peri wound Oedema resolution day (r value=0.403, p value=0.000), Disinfection day (r value=0.262, p value=0.010) and Hospital stay (r value=0.232, p value=0.02) are having significantly positive correlation with wound size for 21 days in both groups.
How to cite this article:
Seelam Paparao and K. Harikrishna Redd. A Study of Efficacy of Topical Super Oxidized Solution in Comparison with Povidone Iodine for the Management of Lower Limb Diabetic Ulcers.
DOI: https://doi.org/10.36478/10.36478/makrjp.2025.1.7.11
URL: https://www.makhillpublications.co/view-article/1815-9362/10.36478/makrjp.2025.1.7.11