files/journal/2022-09-03_18-54-37-000000_456.png

Research Journal of Pharmacology

ISSN: Online 1993-6019
ISSN: Print 1815-9362
About US
Editors
Issues
Pages
Indexed in
92
Views
2
Downloads

Comparative Clinical Study of 0.5% Hyperbaric Bupivacaine Alone and 0.5% Hyperbaric Bupivacaine with Midazolam Intrathecally for Lower Limb Orthopaedic Surgeries

Sruthi , T. Sinduja and C. Madhushri
Page: 16-21 | Received 15 Aug 2024, Published online: 28 Oct 2024

Download Citation
https://doi.org/10.36478/10.36478/makrjp.2024.4.16.21

Full Text Reference XML File PDF File

Abstract

In order to maximize the quality of anaesthesia by increasing the duration of action and maximising post operative analgesia, a number of adjuvants have been added to spinal local anaesthetics. The present was aimed to study efficacy and analgesic effect of mixture of midazolam‐bupivacaine as compared to bupivacaine alone in patients undergoing lower limb orthopaedic surgery under subarachnoid block. Material and Methods: Present study was prospective randomized case control study, conducted patients of either sex aged between 18‐60 years, belonging to ASA Grade I and II, undergoing lower limb orthopaedic surgeries. All patients were randomly allocated into two groups (each group consisting of 50 patients) as Group B(control group received 0.5% hyperbaric Bupivacaine alone) and Group M(study group received 0.5% hyperbaric Bupivacaine+1 mg of Preservative free Midazolam (0.2 ml) intrathecally). In group B, mean onset time for sensory blockade was 4.76±0.76 minutes as compared to 3.68±1.06 minutes in the group M, difference was statistically significant. Mean duration of sensory blockade in group B is 88.96±2.98 minutes were as in group M, it is 119.70±8.93 minutes, p<0.05 hence statistically significant. Mean duration of maximum motor blockade in B is 161.66±15.58 while in group M, the mean duration of maximum motor blockade is 166.0±12.46 minutes, difference was not statistically significant. In group B, the mean duration of analgesia is 124.86±7.25 minutes as compared to 247±25.74 minutes in group M, p value is 0.000 (p<0.05), hence statistically highly significant. Intrathecal preservative free midazolam 1 mg in combination with hyperbaric bupivacaine 0.5% appears effective and a safe option for the enhancement of spinal effect and duration of local anaesthestic agent.

How to cite this article:

Sruthi , T. Sinduja and C. Madhushri. Comparative Clinical Study of 0.5% Hyperbaric Bupivacaine Alone and 0.5% Hyperbaric Bupivacaine with Midazolam Intrathecally for Lower Limb Orthopaedic Surgeries.
DOI: https://doi.org/10.36478/10.36478/makrjp.2024.4.16.21
URL: https://www.makhillpublications.co/view-article/1815-9362/10.36478/makrjp.2024.4.16.21