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Research Journal of Pharmacology

ISSN: Online 1993-6019
ISSN: Print 1815-9362
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A Comparative Study of Two Doses of Buprenorphine as an Adjuvant to 0.5% Hyperbaric Bupivacaine for Spinal Anesthesia in Lower Limb Surgeries

Ashik Sreekumar, Sanhita Kulkarni, Anuradha Mohite, Pradnya Joshi, Vasanti Sasturkar and Pramod Bhale
Page: 21-26 | Received 01 Jul 2024, Published online: 08 Aug 2024

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https://doi.org/10.36478/10.36478/makrjp.2024.2.21.26

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Abstract

Buprenorphine is an agonist‐antagonist opioid. Intrathecal buprenorphine in different doses along with local anaesthetics is safe and known to increase the postoperative analgesia without affecting sensory or motor blockade. Aim of the study is to compare the efficacy and safety of two doses of buprenorphine (45 mcg and 60 mcg) as an adjuvant to 0.5% hyperbaric bupivacaine for spinal anesthesia in lower limb surgeries. Prospective randomized double blind study in sixty patients posted for lower limb orthopaedic surgeries under spinal anaesthesia. Group B1 (n=30) received 3 ml of 0.5% hyperbaric bupivacaine with 45 mcg buprenorphine, Group B2 (n=30) received 3 ml 0.5% hyperbaric bupivacaine with 60 mcg buprenorphine, respectively. Following parameters were observed: onset and duration of sensory block and motor block, maximum height of sensory block and duration of postoperative analgesia and side effects if any. Group B2 (3.92±1.47 min) had a faster onset of sensory block when compared to group B1 (4.88± 1.17 min) which was statistically significant (p=0.014). T6 was the maximum height of sensory block attained in both the groups. The mean duration of sensory block was prolonged in Group B2 (182.0±31.1 min) than Group B1 (152.8±16.7 min). This difference was highly significant statistically. (P=0.0000). Group B2 (5.76±1.45 min) had a faster onset of motor block when compared to group B1 (6.88±1.17 min) the results being statistically significant (P=0.004). The mean duration of motor block was prolonged in group B2 (213.6±32.5 min) when compared to group B1 (185.2±21.4 min), the results were statistically highly significant (p=0.001). The duration of analgesia was prolonged in group B2 (306.0±34.4 min) when compared to group B1 (277.2±31.4 min). The results were statistically significant (p=0.003). No major side effects observed in both the groups. Addition of buprenorphine as an adjuvant to hyperbaric bupivacaine in doses of 60 mcg as compared to 45 mcg provides faster onset of sensory and motor block along with prolonged duration of sensory, motor block and post operative analgesia without significant increase in adverse effects.

How to cite this article:

Ashik Sreekumar, Sanhita Kulkarni, Anuradha Mohite, Pradnya Joshi, Vasanti Sasturkar and Pramod Bhale. A Comparative Study of Two Doses of Buprenorphine as an Adjuvant to 0.5% Hyperbaric Bupivacaine for Spinal Anesthesia in Lower Limb Surgeries.
DOI: https://doi.org/10.36478/10.36478/makrjp.2024.2.21.26
URL: https://www.makhillpublications.co/view-article/1815-9362/10.36478/makrjp.2024.2.21.26