Research Journal of Pharmacology
ISSN: Online 1993-6019ISSN: Print 1815-9362
Abstract
Metformin is a widely prescribed medication for the management of type 2 diabetes, known for its efficacy and safety profile. It is generally acknowledged that it enhances insulin signalling, primarily in muscle, liver and adipose tissue and inhibits the synthesis of glucose by the liver. However, concerns have arisen regarding its potential impact on vitamin B12 levels. Vitamin B12 deficiency can lead to various health complications, including anemia and neuropathy. This study aims to investigate the relationship between metformin therapy and vitamin B12 levels in patients with type 2 diabetes. This cross‐sectional study was carried out with 60 patients of type 2 diabetes mellitus of both sexes. They were split into two groups: group A consisted of 30 type 2 diabetes mellitus patients who had been receiving metformin therapy for more than a year and group B included 30 type 2 diabetic patients who had either ceased taking metformin six months prior or were not on it. A chemiluminescence approach was used to assess the amounts of serum vitamin B12. Data was examined statistically. Our findings indicate a statistically significant decrease in vitamin B12 levels among patients receiving metformin therapy when compared to the control group (p<0.002). The reduction in vitamin B12 levels was associated with the duration of metformin therapy and increased metformin dosage. Notably, we observed that patients who had been using metformin for more than two years had a higher risk of developing vitamin B12 deficiency. There is a correlation between metformin and a drop in serum vitamin B12. It is advised that individuals with type 2 diabetes mellitus who are receiving greater dosages or a longer period of metformin medication have an annual evaluation of their serum vitamin B12.
How to cite this article:
Nama Netaji. A Study on Vitamin B12 Levels in Metformin Therapy.
DOI: https://doi.org/10.36478/10.36478/makrjp.2024.1.49.52
URL: https://www.makhillpublications.co/view-article/1815-9362/10.36478/makrjp.2024.1.49.52