Research Journal of Pharmacology
ISSN: Online 1993-6019ISSN: Print 1815-9362
Abstract
Schizophrenia is a complex psychiatric disorder with variable onset age, which influences its clinical manifestations and treatment outcomes. Distinguishing between early‐onset schizophrenia (EOS) and late‐onset schizophrenia (LOS) is crucial for tailoring therapeutic approaches. Objectives: To compare the clinical features and treatment outcomes between EOS and LOS, providing insights into their distinct therapeutic needs and prognostic outcomes. This retrospective cohort study analyzed medical records of 120 patients diagnosed with schizophrenia, divided equally into EOS (onset before 18 years) and LOS (onset after 40 years) groups. Data on clinical features such as auditory hallucinations, delusions, cognitive decline and treatment responses were collected and statistically analyzed to ascertain differences between the groups. EOS patients exhibited a significantly higher prevalence of auditory hallucinations (80% vs. 68.3%, P=0.040), delusions (95% vs. 85%, P=0.023), cognitive decline (58.3% vs. 36.7%, P=0.009) and negative symptoms (83.3% vs. 58.3%, P=0.002) compared to LOS patients. In terms of treatment outcomes, EOS was associated with lower remission rates and higher relapse and hospitalization rates. LOS patients showed relatively milder clinical features and better response to treatments in terms of remission and functional recovery, although these differences were not always statistically significant. The study underscores significant differences in clinical presentations and treatment responses between EOS and LOS, highlighting the need for age‐specific diagnostic and treatment strategies. Early intervention and tailored therapeutic approaches are critical for improving outcomes in EOS, while focusing on managing paranoia and improving functional outcomes can enhance care for LOS patients.
How to cite this article:
Yogesh Avinash Kulkarni and Ragini Malusare. A Comparative Study of Early Onset vs Late Onset Schizophrenia: Clinical Features and Treatment Outcome.
DOI: https://doi.org/10.36478/10.36478/makrjms.2025.1.1.6
URL: https://www.makhillpublications.co/view-article/1815-9362/10.36478/makrjms.2025.1.1.6