Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Aim of this trial was to compare the analgesic efficacy of intrathecal dexmedetomidine or clonidine as adjuvant with isobaric ropivacaine in gynaecological surgery. 90 patients of ASA grade I or II, ages between 20‐60 years, were randomly allocated to three equal groups, Group R received 3ml of isobaric ropivacaine (0.75%) with normal saline as a placebo, group D received 3ml of isobaric ropivacaine (0.75%) with 5 μg of dexmedetomidine and Group C received 3ml of isobaric ropivacaine (0.75%) with 30 μg of clonidine. All solutions were made up to 3.5 ml with addition of normal saline. The onset and duration of sensory and motor blockade, time to reach peak sensory and motor level and the sensory and motor regression times were recorded. Time to use first rescue analgesia, hemodynamic changes and side effects were recorded. Time to onset of sensory block and motor block was earlier in Group D and Group C as compared to Group R. Duration of sensory and motor blockade was prolonged in Groups C and D compared with Group R. The mean regression time to S1 segment was prolonged in Group D, and in Group C compared to Group B. The time to 1st rescue analgesia was significantly prolonged in Group D compared with Group C and group R. Dexmedetomidine when added to intrathecal ropivacaine prolongs the sensory block and provides prolonged postoperative analgesia compared to clonidine.
How to cite this article:
A. Balakrishnan and M. Pradeep. Effect of Dexmedetomidine and Clonidine as Adjuvant to Intrathecal 0.75% Isobaric Ropivacaine in Gynaecological Surgery.
DOI: https://doi.org/10.36478/makrjms.2025.3.83.87
URL: https://www.makhillpublications.co/view-article/1815-9346/makrjms.2025.3.83.87