Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Abstract
Chronic liver disease (CLD) impacts the metabolism of other organs such as bones. The prevalence of hepatic osteodystrophy varies from 13% to 70% in Western countries and is even higher, ranging from 68% to 95%, in India. Studies on serum 25(OH)D concentrations and their correlation with liver disease progression have yielded inconsistent results. Limited studies in Central India have explored the impact of CLD on bone mineral homeostasis. Against this backdrop, this study aims to elucidate the effects of CLD and its severity on various bone mineral metabolism parameters. A cross‐sectional study was conducted at a tertiary care hospital in Central India. The study included 123 cases with confirmed CLD and 123 age‐ and sex‐matched controls selected from the OPD patients. Serum levels of calcium, inorganic phosphate, 25(OH) vitamin D and intact parathyroid hormone (iPTH) were measured. The severity of the disease was graded using the Child‐Pugh‐Turcotte score. Patients with CLD exhibited significantly lower serum calcium and 25(OH)D levels, while serum iPTH levels were significantly higher compared to controls. Regular monitoring of serum calcium, inorganic phosphate and 25(OH)D levels should be integral in CLD patients to facilitate timely interventions for optimal management.
How to cite this article:
Mohd Abass Dar, V. Abhinandhan, Gaurav Akhand and Shashank Tyagi. An Observational Study on the Influence of Chronic Liver Disease on Bone and Calcium Metabolism in Indian Patients.
DOI: https://doi.org/10.36478/10.59218/makrjms.2024.3.346.349
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2024.3.346.349