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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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Determination of Association and Prognostic Value of Cystatin C in Ischaemic and Hemorrhagic Stroke

Monoj Sharma, Ramprasad Atta, Kanika Jana, Srabani Ghosh, Debkumar Ray, Saumik Datta and Md Alamgir Perwana
Page: 465-468 | Received 24 May 2024, Published online: 23 Jun 2024

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https://doi.org/10.36478/10.59218/makrjms.2024.3.18.465.468

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Abstract

Cystatin C (Cys C) is also known as Cystatin 3. It is a protein inhibitor of cysteine protease. Cystatin C is encoded by the CST3 gene by all nucleated cells ( DNA containing cells) at a constant rate. Cystatin C is a protein consists of 120 Amino Acids and contained by all tissues and body fluids (normal blood serum cystatin C value is between 0.6 and 1 mg L‾1). To determine serum Cystatin C levels in patients with ischaemic and hemorrhagic stroke. The present study was a Hospital based Longitudinal Comparative study. This Study was conducted for one and half year at Department of Medicine and Department of Biochemistry of Burdwan Medical College and Hospital. Total 120 patients were included in this study. In Hemorrhagic stroke , the mean Cystatin-C value within 24 hrs of stroke (mg L‾1) (Mean±S.D.) of patients was 1.1665±0.3495. In Ischaemic stroke, the mean Cystatin-C value within 24 hrs of stroke (mg L‾1) (Mean±S.D.) of patients was 1.5987±0.4432. Distribution of mean Cystatin-C value within 24 hrs of stroke (mg L‾1) with Group was statistically significant (p<0.0001). In Hemorrhagic stroke, the mean Cystatin-C value at end of 1st week of stroke (mg L‾1) (Mean±S.D.) of patients was 1.1728±0.3539. In Ischaemic stroke, the mean Cystatin-C value at end of 1st week of stroke (mg L‾1) (Mean±S.D.) of patients was 1.5087±0.4187. Distribution of mean Cystatin-C value at end of 1st week of stroke (mg L‾1) with Group was statistically significant (p<0.0001). In Hemorrhagic stroke, the mean Cystatin-C value at end of 2nd week of stroke (mg L‾1) (Mean±S.D.) of patients was 1.1810±0.3040. In Ischaemic stroke, the mean Cystatin-C value at end of 2nd week of stroke (mg L‾1) (Mean±S.D.) of patients was 1.3792±0.4214. Distribution of mean Cystatin-C value at end of 2nd week of stroke (mg L‾1) with Group was statistically significant (p<0.0001). In conclusion, this study on the association and prognostic value of cystatin C in ischemic and hemorrhagic stroke reveals significant findings that could enhance stroke prognosis and management. Elevated cystatin C levels were found to be associated with the severity and outcomes of both types of stroke, suggesting that cystatin C could serve as a valuable biomarker for assessing stroke prognosis.

How to cite this article:

Monoj Sharma, Ramprasad Atta, Kanika Jana, Srabani Ghosh, Debkumar Ray, Saumik Datta and Md Alamgir Perwana. Determination of Association and Prognostic Value of Cystatin C in Ischaemic and Hemorrhagic Stroke.
DOI: https://doi.org/10.36478/10.59218/makrjms.2024.3.18.465.468
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2024.3.18.465.468