Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Comparison of Analgesic Effects of Fentanyl, Dexmedetomidine Alone and Combination of Fentanyl and Dexmedetomidine Intrathecally in Active Iabor: A Randomized Control Trial
Amit Verma, Ajay Bajpai, Himanshu Chhagan Bayad and Ankit Kumar
Page: 29-34 | Received 18 Aug 2023, Published online: 01 Sep 2023
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Abstract
Labor pain is one of the most severe pains the majority of women endure in their lifetime. Effective pain control during childbirth has long been an important health and sociological issue throughout the world and remains so even today. Combined spinal‐epidural anaesthesia (CSE) has the advantages of spinal analgesia along with the benefits of epidural analgesia that can be maintained throughout the entire duration of labor. To compare the analgesic effects of administering fentanyl, dexmedetomidine and combination of fentanyl and dexmedetomidine intrathecally in active labor and to evaluate the side effects of fentanyl and dexmedetomidine on mother and new born. A prospective randomized controlled trial was carried out at a tertiary healthcare centre of North India over a period of 7 years. 90 patients participated in this study. These were divided into three groups randomly based on the labor analgesic drugs they recieved and results were analyzed statistically. dxmedetomidine 10 μg aloneand dexmedetomidine 5 μg in combination with 10 μg fentanylused in our study were able to achieve adequate labor analgesia which was comparable to fentanyl alone (group F) as suggested by equivalent minimum VAS (below 2, p = 0.670) among all three groups. Pruritus was the notable side effect with fentanyl (group F, total 6 incidents out of 30 parturients) which was significantly higher than both the groups (group D and Group F+D) (p = 0.021). When dexmedetomidine is combined with fentanyl (group FD) this combination led to longest duration of analgesia among three groups which shows the possibility of synergistic effect of both these drugs without affecting maternal hemodynamics and neonatal outcome.
How to cite this article:
Amit Verma, Ajay Bajpai, Himanshu Chhagan Bayad and Ankit Kumar. Comparison of Analgesic Effects of Fentanyl, Dexmedetomidine Alone and Combination of Fentanyl and Dexmedetomidine Intrathecally in Active Iabor: A Randomized Control Trial.
DOI: https://doi.org/10.36478/10.59218/makrjms.2023.8.29.34
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2023.8.29.34