Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
The study investigates the relationship between respiratory microbiota and lung function in asthma patients, shedding light on the microbial components contributing to asthma pathophysiology. A cohort of 100 participants, comprising 50 asthma patients and 50 healthy controls, was examined. The asthma group exhibited varying severity levels: mild (20 patients), moderate (20 patients) and severe (10 patients). Alpha‐diversity indices (Shannon and Simpson) revealed significantly reduced microbial diversity in asthma patients compared to controls (p<0.01). Dominant microbial species were identified, with Haemophilus, Neisseria and Moraxella being prevalent in asthma patients, while Streptococcus, Prevotella and Veillonella were dominant in healthy controls. Correlation analysis demonstrated a significant negative correlation between Haemophilus abundance and lung function (FEV1) in asthma patients (r = ‐0.65). Notably, severe asthma patients displayed higher Haemophilus and Moraxella abundance, alongside reduced microbial diversity. Asthma patients exhibited impaired lung function, characterized by lower FEV1 and FVC, which correlated with specific microbial profiles. Corticosteroid treatment induced shifts in microbiota, including decreased Haemophilus and increased Streptococcus abundance. Elevated inflammatory markers (eosinophils and IGE) were observed in asthma patients, with positive correlations to Haemophilus and Moraxella abundance (r = 0.55 and r = 0.60, respectively). This study underscores the impact of respiratory microbiota on lung function in asthma, providing insights into the role of specific bacterial taxa and their associations with disease severity and treatment response. These findings suggest potential avenues for microbiota‐based therapeutic interventions in asthma management, emphasizing the need for personalized approaches considering microbial composition and host inflammatory status.
How to cite this article:
K.P. Prasad Babu, P. Sumangali, K. Akshitha and G. Venkata Mahesh. The Association Between Respiratory Microbiota and Lung Function in Asthma Patients.
DOI: https://doi.org/10.36478/10.59218/makrjms.2023.8.175.180
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2023.8.175.180