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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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Evaluation of Serum Ferritin as a Surrogate Marker of Hyperlipidemia in Children with Beta Thalassemia Major

Pritish Mohapatra, Subash Chandra Majhi, Prakash Chandra Panda, Chandrakant Poddar and Deepak Ranjan Bhol
Page: 139-144 | Received 18 Aug 2023, Published online: 04 Sep 2023

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https://doi.org/10.36478/10.59218/makrjms.2023.8.139.144

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Abstract

Thalassemia refers to a group of genetic disorders of globin chain production in which there is imbalance between the alpha‐ globin and beta‐globin chain production. Thalassemia is one of the major hemoglobinopathies among the population all around the world. It has been reported that now a days approximately 1 out of 14 people are carriers for different subtypes of thalassemia. 1lakh thalassemia children are born every year in the world with birth rate of 22.8/10000. In India 10000 thalassemia children are born every year. To find out the correlation between serum ferritin and lipid profile status in beta thalassemia major patients in 5‐14 years age group. A cross sectional analytical study was conducted where 227 children with beta thalassemia major in the age group 5‐14 years from the Thalassemia unit of Veer Surendra Sai Institute of Medical Science and Research (VIMSAR) who were on regular blood transfusion and oral iron chelators were enrolled. Serum ferritin levels, lipid profile status and baseline red cell indices were investigated and their correlation assessed. Out of total 227 children, 141 (62.1%) were of 11 years or above, with male predominance of 60.4% among 227 patients. Only 46 (20.3%) had a history of consanguinity which was statistically significant with a p<0.0001. Hematological tests showed the mean pre‐transfusion haemoglobin level was 6.0863 g dL-1 with a standard deviation of 1.10. Mean MCHC was on the lower side at 25.26 g dL-1 (SD:2.24) and mean MCV was 87.32fl (SD:2.25). The mean value of Serum ferritin was 2924.79±1697.12 ng mL-1. Mean value of Total cholesterol, HDL‐ cholesterol, LDL‐cholesterol were 139.94±15.23, 41.92±5.86, 103.04±7.32 mg dL-1, respectively and their correlation with serum ferritin were negative (r = ‐0.909, r = ‐0.935 and r = ‐0.882, respectively). Mean value of serum Triglyceride was 188.06±26.43 and it had positive correlation with serum ferritin with r = 0.860. We observed that, there was significant derangement in lipid profile status correlating with serum ferritin values in a beta thalassemia major patient. As the serum ferritin value increases serum triglyceride level increases and serum total cholesterol, HDL cholesterol, LDL cholesterol value decreases.

How to cite this article:

Pritish Mohapatra, Subash Chandra Majhi, Prakash Chandra Panda, Chandrakant Poddar and Deepak Ranjan Bhol. Evaluation of Serum Ferritin as a Surrogate Marker of Hyperlipidemia in Children with Beta Thalassemia Major.
DOI: https://doi.org/10.36478/10.59218/makrjms.2023.8.139.144
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2023.8.139.144