Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Abstract
The prevalence of prostate cancer (PCa), a prevalent tumour, is rising globally. PSA, or serum prostate‐specific antigen, is frequently utilised in PCa screening. Malignancies are thought to be largely influenced by inflammation and there is a complicated connection between the local immune response and systemic inflammation. Inflammatory characteristics have been researched as a potential PCa diagnostic sign. Serum prostate‐specific antigen (PSA) which is used to detect PCa does not have enough sensitivity and specificity for PCa, which leads to unnecessary biopsies, overdiagnosis and overtreatment. Therefore, there is a need for easily available and inexpensive new biomarkers that can detect clinically important PCas and prevent unnecessary biopsies. Evaluate the predictive role of the inflammatory parameter, especially MLR, on the diagnosis of Pca. A retrospective study was conducted from June 2021 to July 2022 in Vydehi institute of medical science and research centre, Bangalore. Patients who presented with obstructive LUTS were included in this study and were analyzed. In 1 year period a total of 44 patients with a PSA >4 were assessed. MLR had a Sensitivity: 87.5% and Specificity: 97.2% with a p value of 0.001 which was highly significant in detecting prostate cancer in patients subjected to biopsy Other inflammatory markers like NLR and PLR had a Sensitivity: 75%, Specificity: 50% and Sensitivity: 75%, Specificity: 81%, respectively. All inflammatory markers evaluated in our study like NLR, PLR and MLR were high in PC apatients. But only MLR value had high sensitivity and specificity in detecting prostate cancer in patients with elevated PSA.
How to cite this article:
J. Chaithanya, M. Dileep, P. Sanjay, K. Venkateshwara and M. Kunal. Monocyte to Lymphocyte Ratio as a Marker to Predict Carcinoma Prostate in Prostate Biopsy.
DOI: https://doi.org/10.36478/10.59218/makrjms.2023.175.180
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2023.175.180