Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Abstract
PROM occurs in 10% of all pregnancies and is a major cause of preterm birth and perinatal mortality and morbidity. Clinicians are usually uncertain regarding the diagnosis of PROM based on examination and history alone. A misdiagnosis often leads to unnecessary interventions that may be detrimental to mother and fetus. There is currently no ideal non‐invasive diagnostic test that can diagnose prolabor rupture of membranes with certainty. This study aims to evaluate the reliability of vaginal fluid creatinine for the diagnosis of PROM in female with singleton pregnancies at 28‐42 weeks of gestation. A prospective case control study was performed at Kamla Raja Hospital for a period of 2 year from November 2020 to October 2022. Sample size 200 patients was taken and divided into 2 groups, 100 study group and 100 controls. Out of 100 study group, 50 were in study group 1 (confirmed cases) and 50 in study group II (suspected cases). Patients with history of leaking PV and positive amniotic fluid flow from the cervix were included in group I and patients with history of leaking PV but no amniotic fluid flow from the cervix were included in group II. Vaginal fluid creatinine cut off value set at 0.45 mg/dl has a higher sensitivity (100%) and specificity (82.4%), PPV (66.7%) and NPV (100%) than other tests. P value was <0.001. Vaginal fluid creatinine determination for the diagnosis of PROM is reliable, simple, rapid, and inexpensive.
How to cite this article:
Chetna Agrawal, Archana Maurya, Vibha Dhruv and Paribhashita Mishra. A Prospective Case‐Control Study on Vaginal Fluid Creatinine for the Detection of Premature Rupture of Membrane (PROM).
DOI: https://doi.org/10.36478/10.59218/makrjms.2023.12.89.93
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2023.12.89.93