Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Schizophrenia is a debilitating condition that affects 1% of the population world wide. There is dopaminergic pathophysiology as per the dopamine (DA) hypothesis. We studied the efficacy of antipsychotic treatment in patients with schizophrenia as measured by Positive and Negative Syndrome Scale (PANSS), Clinical Global Impression Severity (CGI‐S) Scales, Calgary Depression Scale for Schizophrenia (CDSS) in a prospective hospital based study in which 141 cases of schizophrenia were enrolled who were receiving antipsychotic medications as per decision of the treating psychiatric units. Baseline data and data at two‐four and six weeks was collected for all subjects using PANSS, CGI‐S and CDSS. The results showed that the patients with schizophrenia showed significant improvement in PANSS scores (positive, negative, general psychopathology and total scores) and in CGI‐S scores after six weeks of treatment with antipsychotics. Thus, antipsychotics improve symptoms in schizophrenia patients by acting on the dopamine pathway thereby providing evidence to the dopamine hypothesis of schizophrenia. Schizophrenia, antipsychotic medications dopamine hypothesis PANSS, CDSS.
How to cite this article:
Parul Prasad and Rameez Shaikh. Effect of Antipsychotic Treatment on Clinical Profile in Patients with Schizophrenia.
DOI: https://doi.org/10.36478/10.59218/makrjms.2023.12.41.44
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2023.12.41.44