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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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Study and Analysis of Clinical Profile and Impact of Neurological Involvement in Disease Progression and Outcome in Patients with Neurological Symptoms in Covid‐19 Positive Patients

Divya Kantak, Vidya Nagar, Shefali Shrivastav, Madhav Mahajan and Ajay Supe
Page: 406-413 | Received 21 Nov 2023, Published online: 16 Dec 2023

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https://doi.org/10.36478/10.59218/makrjms.2023.12.406.413

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Abstract

SARS‐CoV‐2 is an enveloped, single‐stranded ribonucleic acid betacoronavirus. This highly contagious pathogen is transmitted by respiratory droplets and aerosols, direct contact of mucous membranes and probably the fecal‐oral route. The disease manifestations in the infected patients range from mild pneumonia to moderate pneumonia hypoxia requiring hospitalization and critical illness. The virus is believed to enter the CNS via the systemic circulation in the case of severe infection. Acute ischemic stroke is recognized as a neurologic complication of COVID‐19 particularly in elderly, hypertensive and atrial fibrillation patients. The study was performed in the Department of Medicine of a tertiary care teaching hospital from October‐September 2020‐2021. 50 RT‐PCR positive COVID‐ 19 patients presenting with neurological manifestations admitted in the Wards and Intensive Care Unit of dedicated COVID 19 Care Hospital were included in the study. Findings on general and systemic examination along with investigations related to inflammatory markers of interest were collected and data was recorded in a specially designed proforma. Majority of patients presented with right sided (32%) hemiparetic (48%) weakness (62%) as common neurological symptom and were diagnosed with ischemic stroke (38%) with mortality rate of 34%. Majority of patients were diagnosed with midline shift (14%) on brain CT scan with parietal area (10%) and superior sagittal sinus (12%) as commonly affected areas. Non survivors and patients with moderate and severe COVID 19 infection diagnosed with Ischemic stroke tended to have NIHSS scores >4 and higher ICH Score. During the epidemic period of COVID‐19, when examining patients with these neurologic manifestations, clinicians should consider SARS‐CoV‐2 infection as a differential diagnosis to avoid delayed diagnosis or misdiagnosis and prevention of transmission.

How to cite this article:

Divya Kantak, Vidya Nagar, Shefali Shrivastav, Madhav Mahajan and Ajay Supe. Study and Analysis of Clinical Profile and Impact of Neurological Involvement in Disease Progression and Outcome in Patients with Neurological Symptoms in Covid‐19 Positive Patients.
DOI: https://doi.org/10.36478/10.59218/makrjms.2023.12.406.413
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2023.12.406.413