files/journal/2022-09-03_18-51-40-000000_599.png

Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
About US
Editors
Issues
Pages
Indexed in
142
Views
15
Downloads

Clinicopathological Analysis of Ovarian Tumours: The Tertiary Cancer Care Institutional Perspective

Archana Rathod, Bhakti Kalyankar, Jyoti Kodgire, Narendra Patil, Shrikrishna Chavan, Sanjay Pagare, Rakesh Ajmera and L. Deeksha
Page: 357-360 | Received 21 Nov 2023, Published online: 15 Dec 2023

Download Citation
https://doi.org/10.36478/10.59218/makrjms.2023.12.357.360

Full Text Reference XML File PDF File

Abstract

Ovarian malignancy ranks as the second most prevalent cancer of the female reproductive system, accounting for roughly 30% of all cancers affecting the female genital tract. GLOBOCAN 2020 statistics reveal that 1.6% of new cases and 2.1% of deaths across all sites are attributed to ovarian cancer. Ovarian tumors exhibit diverse histogenesis, clinical behavior and malignant potential. Early and accurate diagnosis is critical for effective management and favorable prognosis. The prognosis of ovarian tumors hinges on histological subtype, tumor stage and grade. Histological subtyping is conducted using the WHO classification and the International Federation of Gynecology and Obstetrics staging system. This study aims to investigate the clinico‐pathological patterns of ovarian tumors, contributing valuable data to the current understanding of their demography and clinicopathological spectrum. Additionally the study seeks to classify these tumors according to the WHO classification system. A retrospective observational study was conducted, encompassing 205 patients who presented with ovarian tumors and underwent surgical intervention over a 10‐year period (January‐December 2013‐2022) at the Department of Gynecological Oncology. Informed consent was obtained from all participants. The study included women who underwent surgery for ovariotomy alone or in conjunction with hysterectomy and staging laparotomy. Cases managed conservatively were excluded. Data pertaining to age, clinical symptoms and histopathology were collected. Histopathological examination of the specimens was performed by the Department of Onco‐pathology of the hospital, adhering to appropriate staining procedures (Hematoxylin and Eosin staining). The histopathological reports (HPR) were based on the WHO classification of ovarian tumors (2010). Categorical variables were presented as frequencies and percentages (%) while continuous variables were expressed as Mean±SD and median. Data were entered into an MS Excel spreadsheet, and tables were generated for analysis. Among the 205 patients the median age of presentation was 46.5 years (range 8‐77 years). Bilateral tumors were detected in 39.45% of cases. Malignant tumors constituted 60.54% of the total, while benign and borderline tumors accounted for 29.18% and 10.27%, respectively. Epithelial tumors represented the major bulk of neoplasms at 82.16%, followed by germ cell tumors (10.27%) and sex cord stromal tumors (6.48%). Within the category of surface epithelial tumors, serous tumors were the most common, accounting for 65.78%. Serous cystadenoma emerged as the most frequently encountered benign tumor, followed by mucinous cystadenoma. Serous cystadenocarcinoma was identified as the most prevalent malignant neoplasm, followed by mucinous cystadenocarcinoma. Among germ cell tumors, mature cystic teratoma held the majority at 42.10%. Granulosa cell tumors dominated the sex cord stromal tumor category, constituting 66.66% of all cases. The study demonstrates that surface epithelial tumors are the most common type of ovarian tumor, followed by germ cell tumors. Notably the study encountered a higher prevalence of malignant ovarian tumors, likely due to the tertiary care setting. Approximately 39.45% of cases were diagnosed with bilateral tumors and the peak incidence was observed in the 41‐50 age group. These findings provide valuable insights into the clinico‐pathological spectrum of ovarian tumors, contributing to the advancement of research and clinical practice in this area.

How to cite this article:

Archana Rathod, Bhakti Kalyankar, Jyoti Kodgire, Narendra Patil, Shrikrishna Chavan, Sanjay Pagare, Rakesh Ajmera and L. Deeksha. Clinicopathological Analysis of Ovarian Tumours: The Tertiary Cancer Care Institutional Perspective.
DOI: https://doi.org/10.36478/10.59218/makrjms.2023.12.357.360
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2023.12.357.360