Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Abstract
Obstructive sleep apnea (OSA) is a prevalent sleep disorder associated with various clinical and biochemical factors. This study explores the relationship between OSA and these factors, drawing on institutional experience and relevant research. A prospective observational study was conducted at a tertiary care center, involving 80 adult OSA patients. Clinical, biochemical, sleep‐related, cardiovascular, neurocognitive, genetic and lifestyle parameters were assessed. OSA patients exhibited diverse clinical profiles, including obesity, hypertension, diabetes, cardiovascular disease and daytime sleepiness. Polysomnography indicated varying OSA severity. Biochemical markers showed inflammation, altered glucose metabolism, dyslipidemia and adipokine dysregulation. Sleep parameters included disrupted sleep, low oxygen saturation and high respiratory disturbance. Cardiovascular parameters reflected heart rate variability and blood pressure changes during sleep. Neurocognitive assessments revealed daytime sleepiness and cognitive impairment. Genetic markers and quality of life scores provided additional insights. Lifestyle factors like diet, exercise, medication and sleep position were also assessed. OSA is a complex disorder with diverse clinical and biochemical manifestations. Institutional experiences provide valuable insights into its management and the impact of interventions like CPAP therapy. Understanding these factors is crucial for personalized OSA management and improving patient outcomes.
How to cite this article:
M. Dhanamurthy Koppu, Niaz Farhat, Karnala Sahithi and Fayaz Shaike. Assessment of Clinical and Biochemical Associations in Obstructive Sleep Apnea: An Institutional Experience.
DOI: https://doi.org/10.36478/10.59218/makrjms.2023.12.341.345
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2023.12.341.345