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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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Comparison of Genexpert MTB/RIF, Truenat and Conventional Methods for the Diagnosis of Tuberculosis at a Tertiary Care Centre in Northern Region of India

Shweta Bajpai, Ritika Tiwari, Amit Kumar Singh and K. Ramanath
Page: 316-324 | Received 10 Oct 2023, Published online: 15 Dec 2023

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https://doi.org/10.36478/10.59218/makrjms.2023.12.316.324

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Abstract

Tuberculosis, an infectious disease caused by Mycobacterium tuberculosis, remains a major threat to public health. TB is usually divided into two main categories depending on the MTB infection site pulmonary and extrapulmonary tuberculosis. On the other hand, the sensitivity of conventional acid‐fast bacilli smear is unsatisfactory and MTB culture is time‐consuming. Nucleic acid amplification tests are a major advance in the diagnosis of TB. The Xpert MTB/RIF assay and Truenat also in nowadays are the most widely used NAATs for diagnosing TB and has demonstrated good diagnostic performance in PTB and EPTB. A total of 500 specimens were collected during this study from suspected Pulmonary and Extrapulmonary tuberculosis cases from different wards and outpatient departments Patients with known clinical diagnosis other than the disease, patients already on ATT and patients with HIV infection were excluded from the study. Out of 205 pulmonary and 295 extrapulmonary suspected tuberculosis patients, 32 were positive from pulmonary tuberculosis patients While in extrapulmonary tuberculosis patients 28 were positive. Nucleic acid amplification tests analysis can be effectively used as a quick and accurate diagnostic test for the diagnosis of pulmonary tuberculosis especially in a low resource setting. Pulmonary and Extrapulmonary tuberculosis, MDR‐TB, AFB Staining Culture, Nucleic acid amplification tests.

How to cite this article:

Shweta Bajpai, Ritika Tiwari, Amit Kumar Singh and K. Ramanath. Comparison of Genexpert MTB/RIF, Truenat and Conventional Methods for the Diagnosis of Tuberculosis at a Tertiary Care Centre in Northern Region of India.
DOI: https://doi.org/10.36478/10.59218/makrjms.2023.12.316.324
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2023.12.316.324