Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
According to conjecture, oxidative stress and dyslipidemia are linked to psoriasis inflammation. This complex interplay is thought to be the mechanism behind the development of future CVD risk. In order to assess systemic inflammation, oxidative stress, and the apolipoprotein B/A1 ratio in patients with active psoriasis. Venoscent punctures were used to obtain roughly 10 milliliters of blood from patients who had fasted overnight and placed in sterile EDTA vials. Total cholesterol, triglycerides, and HDL cholesterol were the three components of the plasma lipid profile that were analyzed enzymatically using a kit purchased from (Randox Laboratories Limited, Crumlin, UK). Using the immunoturbidity method (Randox kit), plasma apolipoproteins B and A1 were measured, and the ratio of ApoB to A1 was determined. In comparison to healthy controls, psoriasis patients show negligible variance (ps<0.1) in their age and blood pressure. Table 2 displays markers of the state of oxidative stress and systemic inflammation. In comparison to the healthy control group, the patient group’s plasma CRP and erythrocyte MDA levels were found to be significantly higher (p<0.001, 41.02% and p<0.05, 29.3% high), indicating the importance of inflammation and oxidative stress in the disease process. Based on current research, it is suggested that in addition to lipid profile, apolipoproteins and indicators of oxidative stress and inflammation should be routinely assessed in order to anticipate CVD complications.
How to cite this article:
Prity Ahuja and Sudhir Sharma. A Study on Assessment of Systemic Inflammation, Oxidative Stress and Apolipoprotein B/A1 Ratio in Active Psoriasis Patients.
DOI: https://doi.org/10.36478/10.59218/makrjms.2014.173.177
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2014.173.177