Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Increased irritability of the brain is considered as a cause of migraine. Factors like low serum magnesium levels and mitochondrial abnormalities are responsible for increased irritability of the brain and touted to be responsible for pathophysiology of migraine. The primary aim of the study is to estimate the serum magnesium level and conduct Event related Potential (ERP) study in migraine subjects and also to find out the association between serum magnesium level and the cognitive function. This study was conducted in 50 clinically diagnosed migraine subjects in the age group of 18‐40 years of both genders and 50 age matched controls of both genders from a similar background were selected for the study. Subjects with a minimum of two years of migraine history were selected for the study from the Neurology outpatient department, Stanley Medical College, Chennai, Tamilnadu, India. After eliciting detailed history, General and Clinical examination was done. Cognitive function was assessed using Event related Potential (ERP) study. Serum magnesium level was estimated using Calmagite Dye method by automated analyzer EM‐360. Serum magnesium level was found to be lower in migraine patients compared to healthy controls. This present study shows that there was a significant cognitive impairment in migraine subjects when compared to the control group reflected by Cognitive Evoked potential study. Migraine subjects also have low serum Magnesium level than the control group. The serum magnesium levels were inversely related to the latency in Cognitive Evoked Potential which suggests cognitive impairment in migraine subjects when compared to the control group.
How to cite this article:
V. Rajalakshmi, R. Anbarasi, K. Saravanan and R. Venkatesan. Assessment of Serum Magnesium Level in Migraine Patients in a Tertiary Care Hospital.
DOI: https://doi.org/10.36478/10.36478/makrjms.2025.2.354.361
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2025.2.354.361