Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Anemia of Chronic Disease (ACD) and Iron Deficiency Anemia (IDA) are two prevalent forms of anemia with distinct pathophysiological foundations and clinical manifestations. Differentiating these conditions is crucial for effective treatment but remains challenging due to overlapping clinical features. This study aims to compare the bone marrow findings of ACD and IDA to identify distinguishing features that could enhance diagnostic accuracy. A retrospective analysis was conducted involving 200 patients diagnosed with either ACD or IDA at a tertiary care hospital. Patients were categorized based on standard hematological and clinical criteria. Bone marrow samples were analyzed for cellular morphology, iron stores and other relevant hematological parameters. Statistical analysis included odds ratios, confidence intervals and p‐values to determine the significance of differences between the two groups. The study found significant differences in bone marrow characteristics between ACD and IDA. Hypo‐cellular marrow was more prevalent in ACD (60%) compared to IDA (20%), with an odds ratio (OR) of 0.25 (95% CI: 0.12‐0.52, p=0.001). Conversely, hyper‐cellular marrow was more common in IDA (80%) than in ACD (40%), with an OR of 8.00 (95% CI: 4.88‐13.12, p=0.0001). Additionally, increased iron stores were significantly less frequent in ACD (20%) compared to IDA (95%), resulting in an OR of 0.05 (95% CI: 0.03‐0.08, p=0.00001), while decreased iron stores were predominant in ACD (80% vs. 5% in IDA, OR=80.00, 95% CI: 44.44‐143.90, p=0.00001). Bone marrow examination provides critical insights into the differentiation between ACD and IDA, with distinct patterns evident in cellular morphology and iron storage. These findings support the use of detailed marrow analysis in the diagnostic process, aiding in the selection of appropriate treatment strategies for these anemia types.
How to cite this article:
Santosh D. Gaikwad and Suresh V. Mahajan. Comparative Study of Bone Marrow Findings in Patients with Anemia of Chronic Disease and Iron Deficiency Anemia.
DOI: https://doi.org/10.36478/10.36478/makrjms.2017.6.219.223
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2017.6.219.223