Kübra  Kol, Cüneyt  Toprak, Gökay  Gün, 
    Development of Low Dose Eszopiclone Drug Formulation by Using Geometric Blending
Method,
    Research Journal of Pharmacology,
    Volume 14,Issue 3,
    2020,
    Pages 44-48,
    ISSN 1815-9362,
    rjpharm.2020.44.48,
    (https://makhillpublications.co/view-article.php?doi=rjpharm.2020.44.48)
    Abstract: Eszopiclone is a type of medicine used in the
treatment of insomnia with a hypnotic effect. The aim of
this study is to create Eszopiclone 3 mg tablet formulation
by providing homogeneous distribution of Eszopiclone
raw material which is found in low amount in the drug,
into the Excipients. In order to achieve homogeneous
blending, 4 trial production and pilot studies were carried
out using the geometric blending and elimination method.
Trial 4 was optimized and the process validation study
was approved. Acceptable content uniformity values of
trial 4 and pilot study were calculated as 8.63 and 8.74%,
respectively. In this study, the importance of geometric
blending and elimination method is shown.
    Keywords: Geometric blending;low-dose active ingredients;homogeneous distribution;Eszopiclone;insomnia