H.U. Nwanjo  , N.J.C. Okolie  , G. Oze  , M.C. Okafor  , D. Nwosu  , C. Ajero B. Anyaehie  , G.C. Uloneme  , C.J. Njoku  , P. Nwamkpa  , 
    Changes in Some Biochemical Parameters of Kidney Functions in Rats Co-Administered with Chloroquine and Aspirin,
    Research Journal of Medical Sciences,
    Volume 1,Issue 2,
    2007,
    Pages 106-109,
    ISSN 1815-9346,
    rjmsci.2007.106.109,
    (https://makhillpublications.co/view-article.php?doi=rjmsci.2007.106.109)
    Abstract: This study was done to establish the effects of co-administration of chloroquine with aspirin on kidney function. We monitored renal parameters such as urea, creatinine and electrolytes. The experimental animals were divided into 4 groups. Group 1 received only food and water (control). Group 2-4 received in addition to food and water either single dose with aspirin (8 mg kg <SUP>1</SUP> body weight day <SUP>1</SUP>), chloroquine phosphate (5 mg kg <SUP>1</SUP> body weight day <SUP>1</SUP>) or combined therapy of chloroquine and aspirin for 8 days. The chloroquine-treated group showed a significant increase in mean serum urea and creatinine levels (p< 0.05) and significant decrease in mean serum sodium and potassium levels (p< 0.05) when compared with the corresponding  values  of  the  control  group. This study also revealed that co-administration of chloroquine and  aspirin  caused a more pronounced decrease in serum sodium and potassium levels. The results of the study suggest that acute administration of chloroquine may affect kidney function, more so when co-administered with aspirin; two drugs sometimes combined in the treatment of malaria in a malaria endemic country such as Nigeria.
    Keywords: Chloroquine;aspirin; co-administration; kidney function;biochemical;parameters