Mehrdad  Modaresi, 
    The Effect of Apium Graveolens Extract on Pituitary-Testis Axis in Mice,
    Research Journal of Biological Sciences,
    Volume 9,Issue 3,
    2014,
    Pages 112-114,
    ISSN 1815-8846,
    rjbsci.2014.112.114,
    (https://makhillpublications.co/view-article.php?doi=rjbsci.2014.112.114)
    Abstract: Celery (<I>Apium graveolens</I>) has many therapeutic effects. This plant has 
many phytoestrogens that can affect on the reproductive endocrine system and can 
reduce fertility. In this study, hydro alcoholic extracts of celery leaves on 
the reproductive parameters in young male mice of Balb/C was investigated. The 
samples were randomly divided into 5 groups (3 treatment groups, placebo and control). 
Celery leaves hydro-alcoholic extract in different doses (50, 100, 150 mg/kg/2 
day) was injected (IP) for 20 days. The placebo group was used for injection of 
normal saline. The samples were randomly divided into 5 groups (3 treatment groups, 
placebo and control). After 10 injections, samples bloods were analyzed for FSH, 
LH and testosterone using RIA method. Results showed that concentrations of FSH 
in 100 and 150 mg kg<SUP>-1</SUP> decreased significantly while LH and testosterone concentrations 
in all experimental groups decreased (p&lt;0.05). This study showed dose dependent 
negative effect of celery extracts in male reproductive potential.
    Keywords: LH;FSH;mice;reproductive hormones;Celery extract