Effat Merghati Khoei, Neda Shamsalizadeh, Fatemeh Sheikhan, Mehrdad Fazelimanesh, Anti-Staphylococcal Activity of Zataria multiflora Boiss on Urinary Tract Staphylococcus aureus Infections: A Comparative Study, Research Journal of Biological Sciences, Volume 6,Issue 4, 2011, Pages 187-191, ISSN 1815-8846, rjbsci.2011.187.191, (https://makhillpublications.co/view-article.php?doi=rjbsci.2011.187.191) Abstract: Urinary Tract Infections (UTIs) are considered when pathogens gain access from urethra to upper parts of urinary tract and cause infections. Evaluation of the anti-microbial activity of Zataria multiflora in comparison with antibiotic disks against urine isolates of Staphylococcus aureus is the aim of this study. Microbe suspension equal to Mc Farland 0/5 was prepared and then bacterial strains were transferred to the surface of Muller-Hinton agar with a swab and the susceptibility of the mentioned bacteria was determined by embedding the disks of antibiotics, Zataria multiflora and Betadine (10%), fallowing incubation of the media the inhibition zone around disks were measured. According to antibiogram results, the inhibition zone produced by Zataria multiflora was more than antibiotics and Betadine and it was sensitive in all experiments even in cases that there were no sensitive antibiotics. This comparison showed potential efficiency of anti-Staphylococcus aureus activity for Zataria multiflora and a significant difference between its antimicrobial activity and antibiotics disks obtained. According to increase of drug resistance, further investigations are needed to determine that if it can be useful in management of urinary tract Staphylococcus coagulase positive infections especially when there is no sensitive antibiotic. Keywords: Urinary Tract Infections (UTIs);Z. multiflora;Staphylococcus aureus;anti-microbia;antibiotics;inhibition