Sylvia  Utulu, Adekunle A.  Bakare, 
    DNA Damage Induced in the Germ and Bone Marrow Cells of Mice by Caffeine,
    Research Journal of Biological Sciences,
    Volume 5,Issue 8,
    2010,
    Pages 536-541,
    ISSN 1815-8846,
    rjbsci.2010.536.541,
    (https://makhillpublications.co/view-article.php?doi=rjbsci.2010.536.541)
    Abstract: Caffeine is a major constituent of many drugs and also widely and immensely consumed in beverages and soft drinks. The public health implication of the habitual and indiscriminate consumption of caffeine containing products has prompted studies on its safety evaluation. In this study, we investigated the potentials of caffeine to induce abnormal sperm cells in the testes and Micronuclei (MN) in the bone marrow cells using the sperm morphology and MN assays in mice. For these assays, mice were administered Intraperitoneally (IP) caffeine at dose levels of 0.39, 0.78, 1.56 and 3.12 mg kg<SUP>-1</SUP> bwt (body weight) and normal saline and cyclophosphamide were used as negative and positive controls, respectively.</P>
    Keywords: Caffeine;genotoxicity;mice;micronucleus;spermatozoa;health risk;saline