Ahmad-Ali Khalili , Acute Heart Failure after Evacuation of Large Volume of Pericardial Effusion by Pericardiostomy, Research Journal of Biological Sciences, Volume 3,Issue 1, 2008, Pages 32-34, ISSN 1815-8846, rjbsci.2008.32.34, (https://makhillpublications.co/view-article.php?doi=rjbsci.2008.32.34) Abstract: In this report, we present two cases of acute left ventricular failure after large volume pericardiocentesis. Both cases presented with the symptoms of massive pericardial effusion which documented with Trans-Esophageal Echocardiography (TEE). The case No. 1 had the history of concomitant aortic and Mitral Valve Replacement (MVR and AVR), 2 months before the present admission. The case No. 2 had severe valvular PS and underwent valvotomy, PS repair and PFO occlusion, 2 weeks ago. An emergent pericardiostomy was performed for both cases and approximately 1000 mL of serous fluid was removed. However, after 2 h, the patients complained of symptoms of LV failure. High-dose inotropic support and other supportive measures were considered. The first case dead and the second survived. Keywords: Ventricular failure;pericardial effusion;acute heart failure;evacuation