Giulia Bivona  , Chiara Bellia  , Salvatore Cammarieri  , Bruna Lo Sasso  , Rosachiara Carollo  , Rosalinda Raineri  , Gaia Chiarello  , Antonietta Caruso  , Marcello Ciaccio  , 
    Plasminogen Activator Inhibitor-1-675 4G/5G and Methylenetetrahydrofolate Reductase Gene Variants in Young Acute Myocardial Infarction and Juvenile Ischemic Stroke,
    Research Journal of Biological Sciences,
    Volume 3,Issue 11,
    2008,
    Pages 1341-1343,
    ISSN 1815-8846,
    rjbsci.2008.1341.1343,
    (https://makhillpublications.co/view-article.php?doi=rjbsci.2008.1341.1343)
    Abstract: Cardiovascular diseases often recognize a hereditary-familial genetic risk patterns and a substantial proportion of variability in clinical features of atherosclerosis could probably be explained by genetic factors. Aim of this study is to compare prevalence of factor V Leiden, factor II 20210A, PAI-1-675 4G/5G and MTHFR C677T gene variants in 2 cardiovascular disease clinical features: young acute myocardial infarction (<50 years) and ischemic stroke. Plasminogen Activator Inhibitor-1-675 4G/5G didn’t show significant difference between patients and controls while, between patient groups, the polymorphism was most present in myocardial infarction group than in juvenile stroke. Polymorphisms in Homocysteine metabolism: MTHFR C677T variants was significantly higher in patients with myocardial infarction compared with those affected by ischemic Stroke.
    Keywords: Thrombophilia;stroke;myocardial infarction;gene variants;plasminogen