Jabbari Hossein , Bakhshian Fariba , Asghar Mohammadpoorasl , Attitudes, High-Risk Behaviors and Interaction with Others in Substance Abuse in the Tabriz`s High School Students, Research Journal of Biological Sciences, Volume 2,Issue 7, 2007, Pages 698-701, ISSN 1815-8846, rjbsci.2007.698.701, (https://makhillpublications.co/view-article.php?doi=rjbsci.2007.698.701) Abstract: Adolescent substance abuse potentially holds a number of negative implications for the health and well-being of the individual, including increased risk for injury and death from interpersonal violence, motor vehicle accidents and drowning. There is limited information available on adolescent`s substance abuse in Iran. The main objective of this research is recognition of student`s attitudes, risk behaviors and their connectedness to peers, parents and teachers in relation to addiction. Of all grade-9 and grade-10 students in Tabriz, Iran, 500 were randomly sampled. A self- administered questionnaire was used to collect demographic data, student`s attitudes, risk behaviors and their connectedness to peers, parents and teachers in relation to addiction. The findings showed that 92% of these students denied the usage of the drugs and 10% were used to drugs as a positive mode. But 27% believed that the curiosity is the main factor to get in these drugs and 50% were ashamed of the worst consequences of these drugs. Due to the positive attitude about 10% of the students to the drugs and the results from the different studies can play a great role in prevention of the drugs. Keywords: Adolescent;substance abuse;attitude;risk behaviors