Yasir Hasan Siddique  , Gulshan Ara  , Tanveer Beg  , Mohammad Afzal  , 
    Effect of Vitamin C on Cyproterone Acetate Induced Genotoxic Damage in Mice,
    Research Journal of Biological Sciences,
    Volume 1,Issue 1,
    2006,
    Pages 69-73,
    ISSN 1815-8846,
    rjbsci.2006.69.73,
    (https://makhillpublications.co/view-article.php?doi=rjbsci.2006.69.73)
    Abstract: The genotoxicity study of cyproterone acetate was carried out in mouse bone marrow cells using Sister Chromatid Exchanges (SCEs) and Chromosomal Aberrations (CAs) as a parameter. The effect of cyproterone acetate was studied at 6.25, 12.50 and 25.00 mg kg<SUP>-1</SUP> of body weight and was found to be genotoxic at 12.50 and 25.00 mg kg<SUP>-1</SUP> of body weight. Further the effect of vitamin C on 25.00 mg kg<SUP>-1</SUP> of body weight of cyproterone acetate was also studied. Three doses of vitamin C i.e. 20, 40 and 60 mg kg<SUP>-1</SUP> of body weight were given along with 25.00 mg kg<SUP>-1</SUP> of body weight of cyproterone acetate. Treatments along with vitamin C results in a significant decrease in CAs and SCEs suggesting an antigenotoxic role of vitamin C against cyproterone acetate induced genotoxic damage in mice bone marrow cells.
    Keywords: Cyproterone acetate;vitamin c;chromosomal aberrations;sister chromatid exchanges;mice bone marrow cells