TY  - JOUR
T1  - The Value of Intraoperative Frozen Section in Wide Local Excision for Breast Cancer
AU - Mohd Aripin, Yahya AU - Julianna Osman, Nora AU - Abdul Rashid, Norfaezan AU - Aishah Che Md Ali, Siti 
JO  - Surgery Journal
VL  - 14
IS  - 1
SP  - 1
EP  - 4
PY  - 2019
DA  - 2001/08/19
SN  - 1816-3211
DO  - sjour.2019.1.4
UR  - https://makhillpublications.co/view-article.php?doi=sjour.2019.1.4
KW  - Wide local excision
KW  -breast cancer
KW  -intraoperative frozen section
KW  -patient
KW  -paraffin section
AB  - Wide Local Excision (WLE) is a better
alternative to mastectomy as it preserves the desired
cosmetic outcome without compromising the patient
survival rate. Margin involvement is the main pitfall for
WLE. It leads to reoperation which technically can be
more challenging and potentially causes emotional stress
to the patient. This study evaluates intraoperative Frozen
Section (FS) in determining the margin status during
WLE. All breast cancer patients who underwent wide
local excision were included in the study. In our
institution, intraoperative frozen section for WLE was
started in 2015. This cohort of patients was compared
with earlier patients whom WLE were performed without
frozen section. Patients demographic, tumour
characteristics, margin status and number of reoperations
were analysed. A total of 20 patients aged 43-71
years (mean 56 years) were included in this study. Frozen
sections were performed on the last eight of the patients.
Six patients (30%) had at least one positive margin
involvement. Three patients who had no frozen section
were scheduled for reoperation after 2 weeks. Another
three patients had frozen section and cavity shaving in the
same operation. Total margins evaluated for frozen
section were 39. Out of these, 6 (15.4%) were positive for
malignancy. One (2.6%) was falsely reported as positive
for malignancy. Overall sensitivity and specificity of
frozen section in this study were 100 and 96.9%,
respectively. FS could help surgeon to minimize the
extent of excision during WLE to attain the optimal
cosmetic outcome. Positive margin at FS should be taken
cautiously, especially when it involves decision to convert
the surgery to mastectomy. In that case, it could be wise
to wait for confirmation of the margin status by paraffin
section.
ER  -