TY  - JOUR
T1  - Prophylactic Effects of Meloxicam in <I>E. coli </I>Endotoxin Induced Effects in Camels
AU - AL-Dughaym, A.M. 
JO  - Research Journal of Pharmacology
VL  - 5
IS  - 1
SP  - 1
EP  - 3
PY  - 2011
DA  - 2001/08/19
SN  - 1815-9362
DO  - rjpharm.2011.1.3
UR  - https://makhillpublications.co/view-article.php?doi=rjpharm.2011.1.3
KW  - fibrinogen
KW  -prostaglandins
KW  -camels
KW  -meloxicam
KW  -Endotoxin
KW  -enzymes
KW  -Saudi Arabia
AB  - Intravenous injection of <I>Escherichia coli </I>endotoxin at a dose of 0.1 mg kg<SUP>-1</SUP> body weight to camels caused significant higher temperature and fever lasted initially 9 h, compared to saline treated animals. Endotoxin also caused significant increase in serum concentration of 13, 14-dihydro-15-Keto Prostaglandin F2<SUP>&#945;</SUP> (PGFM), increased activity of Creatine Kinase (CK), Lactic Dehydrogenase (LDH) and Sorbitol dehydrogenase (SH) and decreased concentration of fibrinogen. Intravenous injection of meloxicam, a non-steroidal anti-inflammatory drug at a dose of 0.5 mg kg<SUP>-1</SUP> body weight prior to endotoxin administration significantly (p&lt;0.05) reduced maxim temperature and duration of fever induced by endotoxin. The drug also significantly decreased prostaglandin production but produced no significant effect changes of fibrinogen or enzymes activity, induced by endotoxin injection. It is suggested that meloxicam could prophylactically inhibits endotoxin-induced fever and prostaglandin production in camels.
ER  -