TY  - JOUR
T1  - The Effect of Time Interval Between <sup>99m</sup>T<sub>c</sub> -sestamibi Injection and Image Acquisition on Quantitative Data of Gated SPECT Myocardial Perfusion Imaging at Stress and Rest Phases
AU - Haghighatafshar, Mahdi AU - Alireza Nekooee, MD. AU - Mohammad Entezarmahdi, Seyed 
JO  - Research Journal of Medical Sciences
VL  - 10
IS  - 6
SP  - 683
EP  - 687
PY  - 2016
DA  - 2001/08/19
SN  - 1815-9346
DO  - rjmsci.2016.683.687
UR  - https://makhillpublications.co/view-article.php?doi=rjmsci.2016.683.687
KW  - 99mTc-MIBI
KW  -scintigraphy
KW  -myocardial perfusion
KW  -SPECT
KW  -quantitative myocardial analysis
AB  - According to several recent studies in favor of delayed <sup>99m</sup>T<sub>c</sub> methoxy-isobutyl-isonitrile (<sup>99m</sup>T<sub>c</sub>-MIBI)
redistribution, the aim of this study was to find whether different time intervals between <sup>99m</sup>T<sub>c</sub>-MIBI injection
and image acquisition could affect quantitative data of gated SPECT Myocardial Perfusion Imaging (MPI).
Eighty five patients with moderate pretest probability of coronary artery disease according to &quot;Framingham Risk
Score&quot; enrolled in the study. Myocardial perfusion imaging with SPECT was performed on the basis of two-day
protocol with stress-phase images obtained at 15/180 and rest-phase images obtained at 60/120 minutes after
injection of 666-814 MBq 99mTc-MIBI. Then quantitative data of MPI were obtained and compared at
mentioned time intervals. The changes of five parameters including Summed Stress Score (SSS), Summed
Motion Score (SMS), Summed Thickening Score (STS), Stroke Volume (SV) and Ejection Fraction (EF) were not
significant however; the End Systole Volume (ESV) and End Diastolic Volume (EDV) changes were significant.
Also SSS has not significant changes. The results of this study imply that the time interval between the
injection and acquisition may affect the detection of endocardial and epicardial surfaces in 99mTc-MIBI
myocardial perfusion scanning which afford significant changes in EDV and ESV. While these changes are in
a same direction and correlated so, the functional parameters as EF, SV, SMS and STS do not change
significantly.
ER  -