TY  - JOUR
T1  - Acute and Chronic Toxicity of Iranian Jaft an Oak Fruit Component
AU - Mirzaei, Ali AU - Mirzaei, Noshin 
JO  - Research Journal of Biological Sciences
VL  - 7
IS  - 9
SP  - 350
EP  - 354
PY  - 2012
DA  - 2001/08/19
SN  - 1815-8846
DO  - rjbsci.2012.350.354
UR  - https://makhillpublications.co/view-article.php?doi=rjbsci.2012.350.354
KW  - Acute toxicity
KW  -chronic toxicity
KW  -aqueous extract of Jaft
KW  -biochemical parameters
KW  -hematological parameters
AB  - Oak (<I>Quercus</I> sp.,) fruit has external and internal layers and the internal layer of the fruit is known as Jaft in some parts of Iran. Acute toxicity (LD<SUB>50</SUB>) was estimated by the intraperitoneal (i.p.) and oral (p.o.) routes. For the sub-chronic study, 20 adult Wistar rats were randomly divided into 4 groups (1-4) comprised of 5 animals each. Animals received Jaft extract daily by gavage at doses of 250, 500 and 1000 mg kg<SUP>-1</SUP> for 28 days. At the end of the experiment, blood was collected for hematology and biochemical tests. For histopathological study, liver was dissected and prepared slides with 4-6 mm thick. LD<SUB>50</SUB> of the Jaft extract in p.o. and i.p. route was more than 5000 and 3000 mg kg<SUP>-1</SUP>, respectively. All hematological parameters, with the exception of White Blood Cell (WBC) count, did not significantly differ in the experimental groups compared to the control group. No statistically significant differences were observed in serum cholesterol, triglyceride, blood urea nitrogen, Alkaline Phosphatase (ALP), Glutamate Pyruvate Transaminase (GPT) and Glutamate Oxaloacetate Transaminase (GOT) levels in the treatment groups when compared to the control group. These results suggest that the aqueous Jaft extract could be used safely in humans, particularly by the oral route.
ER  -