TY  - JOUR
T1  - Interaction of  <SUB>2</SUB>-adrenergic System and Caffeine on Passive Avoidance Learning in Male Wistar Rats
AU - , Parichehreh Yaghmaei AU - , Shahrbanoo Oryan AU - , Zahra Hojati AU - , Amirhadi Masoudi AU - , Shahab Amini AU - , Elham Amini 
JO  - Research Journal of Biological Sciences
VL  - 4
IS  - 3
SP  - 327
EP  - 334
PY  - 2009
DA  - 2001/08/19
SN  - 1815-8846
DO  - rjbsci.2009.327.334
UR  - https://makhillpublications.co/view-article.php?doi=rjbsci.2009.327.334
KW  - Clonidin
KW  -yohimbine
KW  -caffeine
KW  -2-adrenergic
KW  -learning
KW  -memory retention
AB  - The effects of co-administration of yohimbine and caffeine on memory impairment induced by clonidine. The effects of yohimbine and caffeine on memory impairment induced by clonidine were measured for memory retention of passive avoidance learning in rats. Post-training intracerebroventricular (i.c.v) injection was carried out in all experiments and optimum doses were identified. The interaction of optimum doses of clonidine, yohimbine and caffeine was investigated on consolidation of step-through passive avoidance memory in rats. Clonidine (2, 4, 6 and 8 &#956;g rat<SUP>-1</SUP>) reduced memory retention, yohimbine (4, 6 and 8 &#956;g rat<SUP>-1</SUP>) and caffeine (10, 20, 30 and 40 &#956;g rat<SUP>-1</SUP>) increased memory retention. Co-administration of the optimum doses of clonidine (6 &#956;g rat<SUP>-1</SUP>) and yohimbine (6 &#956;g rat<SUP>-1</SUP>), showed a statistically significant reduction in the time of step-through latency (p&lt;0.05). Co-administration of the optimum doses of clonidine and caffeine (30 &#956;g rat<SUP>-1</SUP>) showed no significant increase in the time of step-through latency (p&gt;0.2). However, the interaction of caffeine and yohimbine synergistically increased the time of step-through latency. Furthermore, utilization of the three drugs reduced the memory impairment caused by clonidine and potentates consolidation of memory (p&lt;0.05). These results may lay the groundwork for further studies using synergistic effects of caffeine and yohimbine on memory retention.
ER  -