TY  - JOUR
T1  - Pre-Anesthetic Administration of Sublingual Buprenorphine forPostoperative Analgesia after Hemorrhoidectomy a Clinical Trial
AU - , Afsaneh Norouzi AU - , Houshang Talebi AU - , Shaban-ali Alizadeh AU - , Shahin Fateh AU - , Ali Mohamadzadeh AU - , Payam Eghtesadi-Araghi AU - , Fatemeh Djamshidi 
JO  - Research Journal of Biological Sciences
VL  - 4
IS  - 2
SP  - 227
EP  - 230
PY  - 2009
DA  - 2001/08/19
SN  - 1815-8846
DO  - rjbsci.2009.227.230
UR  - https://makhillpublications.co/view-article.php?doi=rjbsci.2009.227.230
KW  - Buprenorphine
KW  -postoperative pain
KW  -hemorrhoidectomy
KW  -randomized
KW  -pre-anesthetic
KW  -administration
AB  - Buprenorphine is classified as an agonist-antagonist mu opioid agonist, which has a longer half-life compared with other opioids. The objective of this study was, to evaluate the efficacy of pre-anesthetic administration of buprenorphine on postoperative pain intensity, in patients undergoing hemorrhoidectomy. In a prospective, double-blinded, randomized study, 60 ASA I and II subjects with age of 15-65 years scheduled for elective hemorrhoidectomy under general anesthesia were enrolled. They were randomly allocated to receive sublingual buprenorphine (0.4 mg, 30 min before surgery) or placebo. All the patients were anaesthetized with halothane N<SUB>2</SUB>O/O<SUB>2</SUB> after induction with thiopentone. Pain scores, as assessed by a visual analog scale, were evaluated immediately, 2, 4 and 6 h postoperatively. Total dose of analgesics and time of the first request for an analgesic medication were measured as well.The pain scores in buprenorphine group were similar to that in control group immediately and 2 h postoperatively. The postoperative pain intensities in 4 and 6 h following surgery were significantly lower in patients receiving buprenorphine compared with control group (3.83&plusmn;2.50 vs. 5.27&plusmn;2.63 and 1.60&plusmn;2.63 vs. 4.40&plusmn;2.59, respectively). Patients in buprenorphine group have a significantly longer time to first analgesic request (3.59&plusmn;0.82 vs. 1.90&plusmn;0.64 h); however, groups were comparable regarding total dose of analgesic consumption.
ER  -