@article{MAKHILLVR20169128042, title = {Evaluation of Tramadol-Midazolam-Ketamine Anesthesia in Rabbits}, journal = {Veterinary Research}, volume = {9}, number = {1}, pages = {1-5}, year = {2016}, issn = {1993-5412}, doi = {vr.2016.1.5}, url = {https://makhillpublications.co/view-article.php?issn=1993-5412&doi=vr.2016.1.5}, author = {C.O.,O.A. and}, keywords = {rabbits tramadol,midazolam,ketamine,Analgesia,respiratory,non-painful procedures}, abstract = {Selected anaesthetic indices of and the heart rate, respiratory rate and rectal temperature responses of 6 healthy rabbits to the intramuscular administration of 2 mg kg–1 midazolam and 25 mg kg–1 ketamine alone (MK) and combined with 4 mg kg–1 tramadol (MKT) were evaluated over a 60 min observation period. Time to loss of righting reflex with MKT (1.7±0.3 min) was significantly (p<0.05) shorter than with MK (4.2±1.5 min). Duration of recumbency with MKT (76.8±5.1 min) and MK (77.8±3.6 min) were similar. Time to standing with MKT (9.3±1.1 min) was shorter than with MK (15.2±2.4 min). Mean heart rates ranged from 204.7±13.0-257.5±3 beats/min with MK and from 207.3±4.6-238.8±8.7 beats/min with MKT. Mean respiratory rates ranged from 33.8±6.2-64.3±15.0 breaths/min with MK from 36.2±2.5-54.0±8.6 breaths/min with MKT. Mean temperature ranged between 38.0±0.2 and 38.9±0.2°C with MK and between 37.9±0.3 and 39.1±0.1°C with MKT. Neither MK nor MKT produced analgesia.} }