@article{MAKHILLRJP202014312518,
    title = {Antiproliferative Activity of <i>Aspergillus terreus</i> Taxol Against Ehrlich Solid Tumor <i>In vivo</i> and
<i>In vitro</i>},
    journal = {Research Journal of Pharmacology},
    volume = {14},
    number = {3},
    pages = {38-43},
    year = {2020},
    issn = {1815-9362},
    doi = {rjpharm.2020.38.43},
    url = {https://makhillpublications.co/view-article.php?issn=1815-9362&doi=rjpharm.2020.38.43},
    author = {Nabila and},
    keywords = {Ehrlich ascites carcinoma,Taxol,ALT,AST,MCF-7,KI67},
    abstract = {Taxol has been approved as a powerful broad
range anticancer drug, however, the accessibility and
pricy of this drug are the main challenges. Thus, fungal
source with feasibility of molecular and nutritional
manipulations could be the alternative promising platform
for bulk production of Taxol. Taxol has been produced by
<i>Aspergillus terreus</i> and its chemical identity has been
validated from our previous work, however, its biological
functionality has not been investigated. Thus, the
objective of the current study was to assess the antitumor
efficiency of <i>A. terreus</i> extracted Taxol (AT-Taxol)
towards EAC solid tumor in male Swiss albino mice.
Ehrlich solid tumor cells were inoculated subcutaneously
into mice, then the animals were injected with AT-Taxol
i.p. and continued for 30 days. AT-Taxol displayed a
significant cytotoxic effect against breast cancers
(MCF-7) by inhibiting the expression of Antigen KI-67,
a nuclear protein associated with the cellular proliferation,
comparing to positive controls. As well as, positive
control mice showed a dramatic increase of serum ALT,
AST activities and liver tissue homogenate lipid
peroxidation rate (MDA) accompanied with decline on
the level of serum albumin that were ameliorated with
AT-Taxol treatment. A plausible reduction on the mice
overall body weight, in addition to tumor weight and
volume with AT-Taxol treatment comparing to positive
controls. From the histo-pathological analysis, AT-Taxol
exhibited a significant improvement on different
pathological features induced by EAC solid tumor
oxidative stress, comparing to positive control mice.}
    }