@article{MAKHILLRJMS20071211556,
    title = {Changes in Some Biochemical Parameters of Kidney Functions in Rats Co-Administered with Chloroquine and Aspirin},
    journal = {Research Journal of Medical Sciences},
    volume = {1},
    number = {2},
    pages = {106-109},
    year = {2007},
    issn = {1815-9346},
    doi = {rjmsci.2007.106.109},
    url = {https://makhillpublications.co/view-article.php?issn=1815-9346&doi=rjmsci.2007.106.109},
    author = {H.U. Nwanjo,N.J.C. Okolie,G. Oze,M.C. Okafor,D. Nwosu,C. Ajero B. Anyaehie,G.C. Uloneme,C.J. Njoku and},
    keywords = {Chloroquine,aspirin, co-administration, kidney function,biochemical,parameters},
    abstract = {This study was done to establish the effects of co-administration of chloroquine with aspirin on kidney function. We monitored renal parameters such as urea, creatinine and electrolytes. The experimental animals were divided into 4 groups. Group 1 received only food and water (control). Group 2-4 received in addition to food and water either single dose with aspirin (8 mg kg <SUP>1</SUP> body weight day <SUP>1</SUP>), chloroquine phosphate (5 mg kg <SUP>1</SUP> body weight day <SUP>1</SUP>) or combined therapy of chloroquine and aspirin for 8 days. The chloroquine-treated group showed a significant increase in mean serum urea and creatinine levels (p< 0.05) and significant decrease in mean serum sodium and potassium levels (p< 0.05) when compared with the corresponding  values  of  the  control  group. This study also revealed that co-administration of chloroquine and  aspirin  caused a more pronounced decrease in serum sodium and potassium levels. The results of the study suggest that acute administration of chloroquine may affect kidney function, more so when co-administered with aspirin; two drugs sometimes combined in the treatment of malaria in a malaria endemic country such as Nigeria.}
    }