@article{MAKHILLRJBS20149311441,
title = {The Effect of Betamethasone Injection on Sexual Hormones Concentration in Female Mice},
journal = {Research Journal of Biological Sciences},
volume = {9},
number = {3},
pages = {102-104},
year = {2014},
issn = {1815-8846},
doi = {rjbsci.2014.102.104},
url = {https://makhillpublications.co/view-article.php?issn=1815-8846&doi=rjbsci.2014.102.104},
author = {Mehrdad,Amir and},
keywords = {Betamethasone,LH,FSH,strogen,progestron,mice},
abstract = {Betamethasone stimulates production of necessary enzymes for
reducing inflammatory responses. This drug is a long-acting steroid which produces
quick anti inflammatory effects with long time effect. Effects of betamethasone
on sexual hormes of female mice were studied in this study. Mice were divided
in 5 groups (control, Placebo and 3 treatments groups) with 10 members in each
group. Samples were kept in similar condition be synchronized in estrus cycle.
Betamethasone was prepared in 0.1, 0.5 and 1 mg kg-1 doses and injected
in peritoneum for 20 days. Control group was not injected while Placebo received
normal saline. After 10 injections blood samples were prepared and the amounts
of LH, FSH, strogen and progestron hormones were evaluated by RIA method. Obtained
results showed that strogen, progesterone and LH were reduced by all treatment
significantly whereas FSH was increased in 0.5 and 1 mg kg-1 groups.
According to results, betamethasone affects sexual hormones dose dependently
and then can affect female sexual potential.}
}