@article{MAKHILLRJBS20072510443,
    title = {Serological Evaluation of Major Beta Thalassemia Patients below15 for Cytomegalovirus Infection in Iran},
    journal = {Research Journal of Biological Sciences},
    volume = {2},
    number = {5},
    pages = {584-589},
    year = {2007},
    issn = {1815-8846},
    doi = {rjbsci.2007.584.589},
    url = {https://makhillpublications.co/view-article.php?issn=1815-8846&doi=rjbsci.2007.584.589},
    author = {H. Choobineh,S.H. Alizadeh,M.K. Sharifi Yazdi,F. Vaezzadeh,H. Dargahi and},
    keywords = {Thalassemia,cytomegalovirus,CMV-IgM,seropositive,patients,ELISA,SPSS},
    abstract = {Thalassemia is one of the most prevalent human genetic diseases. Thalassemia genes are prevalent all over the world especially in countries on Thalassemia belt which Iran is among them. With due attention to the prevalence of this genetic disease in Iran and patients’ vital needs for regularly blood transfusion, it is necessary  to  study  Transfusion-transmitted  cytomegalovirus infection in this patients. Current study has been carried out on 309 Thalassemia patients below 15 who were receiving blood from therapeutic centers repeatedly. ELISA method was used to determine CMV-IgM seroposivity for cytomegalovirus, Also 225 healthy people  below  15  were  selected  as  control group and finally all data were analyzed by SPSS statistical software. The results of this study showed that 12.9 % of under study Thalassemia patients were seropositive for CMV-IgM antibody and 95.1% were negative. Regional separation of patients showed that the patients resided in Tehran are more infected to this virus than patients of other towns. According to this study prevalence of CMV-IgM antibody significantly higher than normal population, therefore immunity care of these patients and use CMV seronegative blood units and also hematic parents (parents with the same blood and CMV seronegative) are important.}
    }